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Monastrol, Tocris Bioscience™

Catalog No. 130550
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective inhibitor of mitotic kinesin Eg5

Potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).

Chemical Identifiers

CAS 254753-54-3
Molecular Formula C14H16N2O3S
Molecular Weight (g/mol) 292.353
InChI Key LOBCDGHHHHGHFA-UHFFFAOYSA-N
Synonym monastrol, ethyl 4-3-hydroxyphenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, 4-3-hydroxyphenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4h-pyrimidin-5-carboxylic acid ethyl ester, d0zk2g, monastrol hplc , solid, inverted exclamation marka-monastrol, 6-methyl-4-3-hydroxyphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, ethyl 6-3-hydroxyphenyl-2-mercapto-4-methyl-1,6-dihydropyrimidine-5-carboxylate, ethyl 6-3-hydroxyphenyl-4-methyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate, ethyl 6-3-hydroxyphenyl-4-methyl-2-thioxo-1,3,6-trihydropyrimidine-5-carboxy late
PubChem CID 2987927
ChEBI CHEBI:75382
IUPAC Name ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
SMILES CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C

Specifications

Quantity 50 mg
Formula Weight 292.35
Percent Purity >98%
Chemical Name or Material Monastrol

Safety and Handling

Recommended Storage Store at Room Temperature
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