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MK 571, Tocris Bioscience™

Catalog No. 233810
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

Potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.

Chemical Identifiers

CAS 115104-28-4
Molecular Formula C26H27ClN2O3S2
Molecular Weight (g/mol) 515.083
InChI Key AXUZQJFHDNNPFG-UXBLZVDNSA-N
Synonym verlukast, chembl15177, 3-3-1e-2-7-chloro-2-quinolinyl ethenyl phenyl 3-dimethylamino-3-oxopropyl thio methyl thio propanoic acid, propanoic acid, 3-3-1e-2-7-chloro-2-quinolinyl ethenyl phenyl 3-dimethylamino-3-oxopropyl thio methyl thio, propanoic acid, 3-3-2-7-chloro-2-quinolinyl ethenyl phenyl 3-dimethylamino-3-oxopropyl thio methyl thio-, e, r-e-verlukast, 3-3-2-7-chloro-2-quinolinyl ethenyl phenyl 3-dimethylamino-3-oxopropyl thio methyl thiopropanoic acid, 5-3-2-7-chloroquinolin-2-yl ethenyl phenyl-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, e-3-3-2-7-chloroquinolin-2-yl vinyl phenyl 3-dimethylamino-3-oxopropylthio methylthio propanoic acid, e-3-3-2-7-chloro-2-quinolinyl ethenyl phenyl 3-dimethylamino-3-oxopropyl thio methyl thio propanoic acid
PubChem CID 5281888
ChEBI CHEBI:6619
IUPAC Name 3-[[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid
SMILES CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O

Specifications

Quantity 10 mg
Formula Weight 515.09
Percent Purity >98%
Chemical Name or Material MK 571

Safety and Handling

Recommended Storage Store at -20°C
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