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Eurofins Discoverx MAPKAP Kinase 2, unactive, 250 µg. (14-349M)
Supplier: Eurofins Discoverx 14349M
Recombinant human MAPKAP Kinase 2 (MAPKAP-K2), amino acids 46-400, A399G, containing an N-terminal GST tag. MAPKAP Kinase 2 has been implicated as a cell cycle checkpoint kinase, joining the ranks of Chk1 and Chk2 as critical regulators of the DNA damage response in mammalian cells in recent studies (Manke, et al, 2005, and Abraham, 2005). This research indicates that MAPKAP Kinase 2, a serine/threonine kinase activated by p38, phosphorylates CDC25 B/C, generating a binding site for 14-3-3 proteins. The checkpoint kinases Chk1 and Chk2 are targets for drug discovery efforts designed to overcome cell cycle arrest due to DNA damage induced by chemotherapeutic agents. For detailed product information, visit www.discoverx.com/proteins.
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