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  8. L 006235, Tocris Bioscience™ 

L 006235, Tocris Bioscience™

Catalog No. 306650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent cathepsin K inhibitor

Potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence.

Chemical Identifiers

CAS 294623-49-7
Molecular Formula C24H30N6O2S
Molecular Weight (g/mol) 466.604
InChI Key FIVYCSWOCXEWSE-UHFFFAOYSA-N
Synonym n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl thiazol-4-yl benzamide, n-1-cyanomethyl amino carbonyl cyclohexyl-4-2-4-methyl-1-piperazinyl-4-thiazolyl benzamide, d0z0pr, basic piperazine-containing compound, 1, n-1-cyanomethyl carbamoyl cyclohexyl-4-2-4-methylpiperazin-1-yl-1,3-thiazol-4-yl benzamide
PubChem CID 9912381
IUPAC Name N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide
SMILES CN1CCN(CC1)C2=NC(=CS2)C3=CC=C(C=C3)C(=O)NC4(CCCCC4)C(=O)NCC#N

Specifications

Quantity 50 mg
Formula Weight 466.6
Percent Purity >98%
Chemical Name or Material L 006235

Safety and Handling

Recommended Storage Store at +4°C
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