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KU 55933, Tocris Bioscience™

Catalog No. 354410
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective ATM kinase inhibitor

Potent, selective and competitive ATM kinase inhibitor (Ki = 2.2 nM, IC50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro. Acts as a radio- and chemosensitizer for the treatment of cancer.

Chemical Identifiers

CAS 587871-26-9
Molecular Formula C21H17NO3S2
Molecular Weight (g/mol) 395.49
MDL Number MFCD08276985
InChI Key XRKYMMUGXMWDAO-UHFFFAOYSA-N
Synonym atm kinase inhibitor, 2-morpholino-6-thianthren-1-yl-4h-pyran-4-one, 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, 2-morpholino-6-thianthren-1-yl-pyran-4-one, 2-morpholin-4-yl-6-thianthren-1-yl pyran-4-one, 2-4-morpholinyl-6-1-thianthrenyl-4h-pyran-4-one, 4h-pyran-4-one, 2-4-morpholinyl-6-1-thianthrenyl, pubchem22474, d05usl, 2-thianthren-1-yl-6-morpholin-4-yl-4h-pyran-4-one
PubChem CID 5278396
IUPAC Name 2-(morpholin-4-yl)-6-(thianthren-1-yl)-4H-pyran-4-one
SMILES O=C1C=C(OC(=C1)C1=CC=CC2=C1SC1=CC=CC=C1S2)N1CCOCC1

Specifications

Quantity 10 mg
Formula Weight 395.49
Percent Purity >98%
Chemical Name or Material KU 55933

Safety and Handling

Recommended Storage Desiccate at -20°C
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