KML 29, Tocris Bioscience™

Description

Highly potent and selective MAGL inhibitor

Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50 = 2.5 nM and >50 μM for 2-AG and AEA respectively).

Specifications

Chemical Identifiers

• CAS: 1380424-42-9
• Molecular Formula: C24H21F6NO7
• Molecular Weight (g/mol): 549.422
• InChI Key: SXHQLPHDBLTFPM-UHFFFAOYSA-N
• PubChem CID: 71656212
• IUPAC Name: 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
• SMILES: C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC(C(F)(F)F)C(F)(F)F

• Quantity: 50 mg
• Synonym: kml29, kml-29, kml 29, 1,1,1,3,3,3-hexafluoropropan-2-yl 4-bis 1,3-benzodioxol-5-yl-hydroxymethyl piperidine-1-carboxylate, 1,1,1,3,3,3-hexafluoropropan-2-yl 4-bis 2h-1,3-benzodioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 4-bis 1,3-benzodioxol-5-yl hydroxymethyl-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-trifluoromethyl ethyl ester
• Formula Weight: 549.42
• Chemical Name or Material: KML 29

Safety and Handling

Recommended Storage

Store at -20°C