Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. N-phenylureas
  8. Ki 20227, Tocris Bioscience™ 

Ki 20227, Tocris Bioscience™

Catalog No. 448150
Click to view available options
Quantity:
10mg
50mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

Inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.

Chemical Identifiers

CAS 623142-96-1
Molecular Formula C24H24N4O5S
Molecular Weight (g/mol) 480.539
InChI Key SHPFDGWALWEPGS-UHFFFAOYSA-N
Synonym 1-4-6,7-dimethoxyquinolin-4-yl oxy-2-methoxyphenyl-3-1-thiazol-2-yl ethyl urea, 1-4-6,7-dimethoxyquinolin-4-yloxy-2-methoxyphenyl-3-1-thiazol-2-yl ethyl urea, 1-4-6,7-dimethoxyquinolin-4-yl oxy-2-methoxyphenyl-3-1-1,3-thiazol-2-yl ethyl urea, pubchem22465, d08bjr, n-4-6,7-dimethoxy-4-quinolinyl o xy-2-methoxyphenyl-n'-1-2-thiazolyl ethyl urea, n-4-6,7-dimethoxy-4-quinolinyl oxy-2-methoxyphenyl-n'-1-2-thiazolyl ethyl urea, n-4-6,7-dimethoxy-4-quinolyl oxy-2-methoxyphenyl-n'-1-1,3-thiazol-2-yl ethyl urea
PubChem CID 9869779
IUPAC Name 1-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-methoxyphenyl]-3-[1-(1,3-thiazol-2-yl)ethyl]urea
SMILES CC(C1=NC=CS1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OC

Specifications

Quantity 50mg
Formula Weight 480.54
Percent Purity >97%
Chemical Name or Material Ki 20227

Safety and Handling

Recommended Storage Store at +4°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.