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  7. JZL 184, Tocris Bioscience™

JZL 184, Tocris Bioscience™

Catalog No. 383650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent MAGL inhibitor

Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors.

Chemical Identifiers

CAS 1101854-58-3
Molecular Formula C27H24N2O9
Molecular Weight (g/mol) 520.494
InChI Key SEGYOKHGGFKMCX-UHFFFAOYSA-N
Synonym unii-7mz1i2j68a, 4-nitrophenyl 4-bis 2h-1,3-benzodioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-dibenzo d 1,3 dioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 1-piperidinecarboxylic acid, 4-bis 1,3-benzodioxol-5-yl hydroxymethyl-, 4-nitrophenyl ester, d0g0mz, 4-bis 1,3-benzodioxol-5-yl hydroxymethyl-1-piperidinecarboxylic acid 4-nitrophenyl ester, 4-nitrophenyl 4-bis benzo d 1,3 dioxol-5-yl hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-dibenzo d 1,3 dioxol-5-yl-hydroxy methyl piperidine-1-carboxylate, 4-nitrophenyl 4-bis 1,3-benzodioxol-5-yl hydroxy methyl-1-piperidinecarboxylate
PubChem CID 25021165
IUPAC Name (4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]

Specifications

Quantity 50 mg
Formula Weight 520.49
Percent Purity >98%
Chemical Name or Material JZL 184

Safety and Handling

Recommended Storage Store at -20°C
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