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Tocris Bioscience™ ITD 1

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

Supplier:  Tocris Bioscience™ 5068/50

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Catalog No. 50-685-0R


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Description

Description

ITD 1 is a selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF-β type II receptor. Inhibits TGF-β-induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells.
Specifications

Specifications

>98%
50 mg
415.52
-20°C
ITD 1
ITD 1
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