Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Benzamides
  8. INCB 3284 dimesylate, Tocris Bioscience™ 

INCB 3284 dimesylate, Tocris Bioscience™

Catalog No. 430650
Click to view available options
Quantity:
10 mg
50mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective CCR2 antagonist

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μ M). Orally bioavailable.

Chemical Identifiers

CAS 887401-93-6
Molecular Formula C28H39F3N4O10S2
Molecular Weight (g/mol) 712.753
InChI Key PNPNUHKICDECDH-SEBNIYPMSA-N
Synonym incb 3284 dimesylate, n-2-3r-1-trans-4-hydroxy-4-6-methoxy-3-pyridinyl cyclohexyl-3-pyrrolidinyl amino-2-oxoethyl-3-trifluoromethyl-benzamide dimethanesulfonate, incb-3284 dimesylate, n-2-3r-1-4-hydroxy-4-6-methoxypyridin-3-yl cyclohexyl pyrrolidin-3-yl amino-2-oxoethyl-3-trifluoromethyl benzamide, n-2-r-1-1r,4r-4-hydroxy-4-6-methoxypyridin-3-yl cyclohexyl pyrrolidin-3-yl amino-2-oxoethyl-3-trifluoromethyl benzamide dimethanesulfonate, n-3r-1-1s,4s-4-hydroxy-4-6-methoxypyridin-3-yl cyclohexyl pyrrolidin-3-yl-2-3-trifluoromethyl phenyl formamido acetamide; bis methanesulfonic acid
PubChem CID 11679268
IUPAC Name N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;methanesulfonic acid
SMILES COC1=NC=C(C=C1)C2(CCC(CC2)N3CCC(C3)NC(=O)CNC(=O)C4=CC(=CC=C4)C(F)(F)F)O.CS(=O)(=O)O.CS(=O)(=O)O

Specifications

Quantity 50mg
Formula Weight 712.76
Percent Purity >98%
Chemical Name or Material INCB 3284 dimesylate

Safety and Handling

Recommended Storage Store at -20°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.