Thermo Scientific™ ImmunoCAP™ Grass Pollen Allergens

Measure specifc IgE antibodies using ImmunoCAP™ allergens, an essential tool to aid in the diagnosis of allergic conditions.

Catalog Number	Mfr. No.	Common Name	Scientific Name	Code	Quantity
14-413-401P	Thermo Scientific™ 14413401	Rye-grass	Lolium perenne	g5	16 Tests
14-413-601P	Thermo Scientific™ 14413601	Meadow grass, Kentucky blue	Poa pratensis	g8	16 Tests
14-410-001P	Thermo Scientific™ 14410001	Timothy grass	Phleum pratense	g6	16 Tests
14-410-101P	Thermo Scientific™ 14410101	Cultivated rye	Secale cereale	g12	16 Tests
14-411-701P	Thermo Scientific™ 14411701	Cocksfoot	Dactylis glomerata	g3	16 Tests
14-413-001P	Thermo Scientific™ 14413001	Sweet vernal grass	Anthoxanthum odoratum	g1	16 Tests
14-413-301P	Thermo Scientific™ 14413301	Meadow fescue	Festuca elatior	g4	16 Tests
14-413-101P	Thermo Scientific™ 14413101	Bermuda grass	Cynodon dactylon	g2	16 Tests
14-413-901P	Thermo Scientific™ 14413901	Velvet grass	Holcus lanatus	g13	16 Tests
14-413-801P	Thermo Scientific™ 14413801	Johnson grass	Sorghum halepense	g10	16 Tests
14-413-701P	Thermo Scientific™ 14413701	Redtop, Bentgrass	Agrostis stolonifera	g9	16 Tests
14-418-801P	Thermo Scientific™ 14418801	Cultivated wheat	Triticum aestivum	g15	16 Tests
14-418-701P	Thermo Scientific™ 14418701	Common reed	Phragmites communis	g7	16 Tests
14-418-901P	Thermo Scientific™ 14418901	Bahia grass	Paspalum notatum	g17	16 Tests
14-423-801P	Thermo Scientific™ 14423801	Brome grass	Bromus inermis	g11	16 Tests
14-424-001P	Thermo Scientific™ 14424001	Meadow foxtail	Alopecurus pratensis	g16	16 Tests
14-423-901P	Thermo Scientific™ 14423901	Cultivated oat	Avena sativa	g14	16 Tests
14-434-401P	Thermo Scientific™ 14434401	Wild rye grass	Elymus triticoides	g70	10 Tests
14-436-001P	Thermo Scientific™ 14436001	Canary grass	Phalaris arundinacea	g71	10 Tests
14-482-101P	Thermo Scientific™ 14482101	Barley	Hordeum vulgare	g201	10 Tests
14-482-201P	Thermo Scientific™ 14482201	Maize, Corn	Zea mays	g202	10 Tests

Description

Quantify specific IgE antibodies with ImmunoCAP™ Grass Pollen Allergens, essential tools to aid in the diagnosis of allergic conditions. IgE antibodies appear in human serum and plasma as a result of sensitization to a specific allergen. Measurement of circulating IgE antibodies provides an objective assessment of sensitization to an allergen. In general, low IgE antibody levels indicate a low probability of allergic disease, whereas high antibody levels to an allergen show a higher correlation with an allergic disease.

ImmunoCAP Specific IgE offers the laboratory:

• Truly quantitative measuring range from 0.1 to 100 kUA/L
• Intra-assay CV (%) comparable to routine clinical chemistry immunoassays
• Excellent consistency over time, and between countries, systems, labs and persons

Expected test values
ImmunoCAP Specific IgE detects IgE antibodies in the range 0.1 to 100 kUA /l, where A represents allergen-specific antibodies. The result is reported quantitatively. In clinical practice, 0.35 kUA /l has commonly been used as a cut-off. A large number of studies have been performed to evaluate the clinical performance of ImmunoCAP Specific IgE tests in allergy diagnosis. Clinical performance is expressed as sensitivity, ranging from 84 to 95%, and specificity, ranging from 85 to 94%. Sensitivity and specificity were reported from multi-center studies including several hundred patients tested for a range of different allergens.

• Specimen collection and preparation
• Use serum and plasma (EDTA or heparin) samples from venous or capillary blood
• Collect blood samples using standard procedures
• Keep specimens at room temperature (RT) for shipping purposes only
• Store at 2–8°C up to one week, otherwise store at –20°C
• Avoid repeated freezing and thawing

Note: Blood samples for testing ImmunoCAP drugs and venom should be collected during or close to the event, preferably not later than 6 months after exposure. If the test result is negative and an IgE-mediated reaction is still strongly suspected, it is advisable to draw a new sample and repeat the test at 5 to 6 weeks.

The presence of specific IgE antibodies is useful to identify the allergens that elicit symptoms and signs of allergy in patients with respiratory allergic diseases including asthma, food allergy, and anaphylactic sensitivity.

Knowing IgE antibody levels provides guidance to clinicians to:

• Identify offending allergens
• Tailor advice to individual patients
• Indicate development of tolerance (food allergy, specific immunotherapy)
• Inform optimized individual medical treatment plans
• Refer to specialists appropriately
• Evaluate whether or not specific immunotherapy is an option

Specific IgE testing also aids in the identification of patients at risk of:

• The allergy march – a progression of skin symptoms to respiratory symptoms
• Severe symptoms including asthma exacerbations – a progression of mild symptoms to severe symptoms
• Progression of recurrent symptoms to persistent symptoms

As in all diagnostic testing, a definitive clinical diagnosis should be made by the clinician after evaluation of all clinical and laboratory findings.

Specifications

• Code Type: Grass