Gibco™ Human WISP-1 Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Catalog Number	Mfr. No.	Quantity
12018100UG	Gibco™ 12018100UG	100 μg
120-18-20UG	Gibco™ 1201820UG	20 μg
12018250UG	Gibco™ 12018250UG	250 μg
12018500UG	Gibco™ 12018500UG	500 μg
120-18-5UG	Gibco™ 120185UG	5 μg

Description

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.

Specifications

• Accession Number: O95388
• Gene ID (Entrez): 8840
• Name: Human WISP-1
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: CCN4
• Conjugate: Unconjugated
• Sequence: TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC NLSCRNPNDI FADLESYPDF SEIAN
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): Functional Assay
• Molecular Weight (g/mol): 38.1
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: AW146261; CCN family member 4; Ccn4; CTC-458A3.8; Elm1; ELM-1; WISP1; WISP-1; WISP1c; WISP1i; WISP1tc; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; Wnt-1 inducible signaling pathway protein 1; Wnt-1-induced secreted protein; WNT1-inducible-signaling pathway protein 1
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized