Gibco™ Human Amphiregulin Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Supplier:  Gibco™ 10055B250UG

Catalog No. 10055B250UG

Description

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

Specifications

• Accession Number: P15514
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 11.3
• Quantity: 250 μg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: AREG
• Conjugate: Unconjugated
• Sequence: SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Gene ID (Entrez): 374
• Name: Human Amphiregulin
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized