Guanidine hydrochloride, 98%, Thermo Scientific Chemicals

Description

Guanidine hydrochloride, CAS # 50-01-1, is an ionic buffer component used for nucleic acids (DNA and RNA) and protein isolation.

Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Guanidine hydrochloride is the hydrochloride salt of guanidine, an acetylcholine releasing agent
• It is a normal product of protein metabolism and is sometimes used for pyrimidine synthesis

Application

• Guanidine hydrochloride is a powerful denaturant, useful for taking nucleic acids (DNA and RNA) and proteins out of their native conformation
• Guanidine hydrochloride acts as a strong organic base at physiological pH
• It is suitable for use in protein and nucleic acid purification protocols

Specifications

Chemical Identifiers

• CAS: 50-01-1
• Molecular Formula: CH6ClN3
• Molecular Weight (g/mol): 95.53
• MDL Number: MFCD00013026
• InChI Key: PJJJBBJSCAKJQF-UHFFFAOYSA-N
• Synonym: guanidine hydrochloride, guanidinium chloride, guanidine, monohydrochloride, aminoformamidine hydrochloride, aminomethanamidine hydrochloride, guanidine monohydrochloride, guanidine hcl, guanidine chloride, iminourea hydrochloride, carbamidine hydrochloride
• PubChem CID: 5742
• ChEBI: CHEBI:32735
• IUPAC Name: guanidine;hydrochloride
• SMILES: C(=N)(N)N.Cl

• Melting Point: 178°C to 185°C
• Density: 1.344
• Quantity: 1000 g
• Beilstein: 3591990
• Sensitivity: Hygroscopic
• Merck Index: 144562
• Solubility Information: Soluble in water and ethanol.
• Formula Weight: 95.53
• Percent Purity: 98%
• Chemical Name or Material: Guanidine hydrochloride

Safety and Handling

Hazard Category	Serious eye damage/eye irritation (category 2), Skin corrosion/irritation (category 2), Acute toxicity (category 4)
Hazard Statement	Causes serious eye irritation, May form combustible dust concentrations in air, Causes skin irritation, Harmful if swallowed or if inhaled
EINECSNumber	200-002-3
RTECSNumber	MF4300000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only