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Tocris Bioscience™ GSK 2830371

Potent and selective allosteric inhibitor of Wip1 phosphatase

Supplier:  Tocris Bioscience™ 5140/10

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Catalog No. 51-401-0


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Description

Description

GSK 2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo. Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable.
Specifications

Specifications

>98%
GSK 2830371
GSK 2830371
10 mg
461.02
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