Evans Blue tetrasodium salt, Tocris Bioscience™

Description

Dye for assessing cell viability and blood brain barrier permeability; also EAAT inhibitor and iGluR antagonist

Potent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist. Also a non-permeating dye, stains damaged plasma membrane and enters in the cytoplasm and nucleus, used for checking cell viability.

Specifications

Chemical Identifiers

• CAS: 314-13-6
• Molecular Formula: C34H24N6Na4O14S4
• Molecular Weight (g/mol): 960.79
• MDL Number: MFCD00004021
• InChI Key: KBNIFDASRCWYGC-GXNXWABVSA-J
• Synonym: evans blue, evansblue, azovan blue, modr evansova czech, blekit evansa polish, evans blue, sodium salt, modr prima 53 czech, ccris 167, c.i. direct blue 53, 1,3-naphthalenedisulfonic acid, 6,6'-3,3'-dimethyl 1,1'-biphenyl-4,4'-diyl bis azo bis 4-amino-5-hydroxy-, tetrasodium salt
• PubChem CID: 24832074
• IUPAC Name: tetrasodium (6E)-4-amino-6-[2-(4'-{2-[(2E)-8-amino-1-oxo-5,7-disulfonato-1,2-dihydronaphthalen-2-ylidene]hydrazin-1-yl}-3,3'-dimethyl-[1,1'-biphenyl]-4-yl)hydrazin-1-ylidene]-5-oxo-5,6-dihydronaphthalene-1,3-disulfonate
• SMILES: [Na+].[Na+].[Na+].[Na+].CC1=CC(=CC=C1N\N=C1/C=CC2=C(C=C(C(N)=C2C1=O)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC=C(N\N=C2/C=CC3=C(C=C(C(N)=C3C2=O)S([O-])(=O)=O)S([O-])(=O)=O)C(C)=C1

• Quantity: 1g
• Formula Weight: 960.82
• Percent Purity: >95%
• Chemical Name or Material: Evans Blue tetrasodium salt

Safety and Handling

Recommended Storage

Store at Room Temperature