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STEMCELL Technologies Etoposide, Size: 500 mg
Supplier: STEMCELL Technologies 1001163
Inhibit proliferation of cancer cells by inhibiting topoisomerase II activity with Etoposide. Highly potent and cell-permeable etoposide inhibits topoisomerase II (IC50 60.3) from religating broken DNA strands by forming a complex with topoisomerase II and DNA which leads to cell death (Wu et al.). Etoposide has also been used as a way to trigger and model cellular senescence in vitro (Bang et al. Te Poele et al. Teng et al. Yang et al.)
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