Dexamethasone acetate, Thermo Scientific Chemicals

Description

Dexamethasone has many uses in the treatment of cancer. Dexamethasone relieves inflammation in various parts of the body. To treat or prevent allergic reactions. As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions. As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma. It is also used for replacement therapy in adrenal insufficiency and in a screening test for the diagnosis of cushing's syndrome. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble at 100 mg/ml in acetone

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, heat.

Specifications

Chemical Identifiers

• CAS: 1177-87-3
• Molecular Formula: C24H31FO6
• Molecular Weight (g/mol): 434.50
• MDL Number: MFCD00027407
• InChI Key: AKUJBENLRBOFTD-RPRRAYFGSA-N
• Synonym: dexamethasone acetate, 11b,16a-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
• PubChem CID: 40469526
• IUPAC Name: 2-[(1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate
• SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(C)=O

• Melting Point: 240°C
• Color: White
• Quantity: 5 g
• Beilstein: 2342608
• Merck Index: 142943
• Solubility Information: Soluble at 100 mg/ml in acetone
• Formula Weight: 434.5
• Physical Form: Powder
• Chemical Name or Material: Dexamethasone acetate

Safety and Handling

Hazard Category	Reproductive toxicity (category 2), Skin sensitisation (category 1), Specific target organ toxicity after repeated exposure (category 2)
Hazard Statement	Suspected of damaging the unborn child, May cause an allergic skin reaction, May cause damage to organs through prolonged or repeated exposure
EINECSNumber	214-646-8
RTECSNumber	TU4050000
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only