Dexamethasone, 98%, Thermo Scientific Chemicals

Description

Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.

Solubility
Soluble in ethanol and dimethyl sulfoxide. Insoluble in water.

Notes
Store in cool place. Light sensitive. Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 50-02-2
• Molecular Formula: C22H29FO5
• Molecular Weight (g/mol): 392.47
• MDL Number: MFCD00064136
• InChI Key: UREBDLICKHMUKA-CXSFZGCWSA-N
• Synonym: dexamethasone, decadron, dexamethazone, maxidex, decaspray, desametasone, hexadecadrol, dexacort, dexasone, hexadrol
• PubChem CID: 5743
• ChEBI: CHEBI:41879
• IUPAC Name: (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
• SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

• Melting Point: ∽260°C (decomposition)
• Assay Percent Range: 0.98
• Quantity: 1 g
• Beilstein: 2066651
• Sensitivity: Light sensitive
• Merck Index: 142943
• Solubility Information: Soluble in ethanol and dimethyl sulfoxide. Insoluble in water.
• Formula Weight: 392.47
• Percent Purity: 98%
• Chemical Name or Material: Dexamethasone

Safety and Handling

Hazard Category	Carcinogenicity (category 2)
Hazard Statement	Suspected of causing cancer
EINECSNumber	200-003-9
RTECSNumber	TU3980000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only