CYP1A2 Monoclonal Antibody (3B8C1), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA3037

Catalog No. 01-670-133

Description

MA3-037 detects Cytochrome P450 1A2 from human and non-human primate samples. MA3-037 has been successfully used in Western blot, immunocytochemistry and immunofluorescence applications. By Western blot, this antibody detects a ∽58 kDa band representing Cytochrome P450 1A2. The MA3-037 immunogen is rat cytochrome P450 protein.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Specifications

• Antigen: CYP1A2
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.05% sodium azide
• Gene Accession No.: P04799, P05177
• Gene Symbols: Cyp1a2
• Immunogen: Rat cytochrome P450 protein.
• Regulatory Status: RUO
• Gene ID (Entrez): 1544, 24297
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: 3B8C1
• Conjugate: Unconjugated
• Gene: Cyp1a2
• Gene Alias: aromatic compound inducible; aryl hydrocarbon hydroxylase; cholesterol 25-hydroxylase; CP12; CYP; Cyp1a1; Cyp1a2; Cyp1a-2; CYPD45; CYPIA2; Cytochrome P(3)450; cytochrome P-448; cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450 family 1 subfamily A member 2; cytochrome P450 family 1 subfamily a polypeptide 1; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450, 1a2; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; Cytochrome P-450d; cytochrome P450-D; Cytochrome P450-P2; cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P(3)450; P3-450; P-448; P450; P450 4; P450 form 4; P450(PA); P450-3; P-450d; P450-D; P450-P3; RATCYPD45; xenobiotic monooxygenase
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate, Rat
• Product Type: Antibody
• Isotype: IgG1