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Cycloheximide, Tocris Bioscience™

Catalog No. 0970100
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Quantity:
100 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of protein synthesis

Selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 μM). Also inhibits ferroptosis. Antifungal antibiotic. Exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.16 μM).

Chemical Identifiers

CAS 66-81-9
Molecular Formula C15H23NO4
Molecular Weight (g/mol) 281.35
MDL Number MFCD00082346
InChI Key YPHMISFOHDHNIV-QTEFRXOUNA-N
Synonym cycloheximide, actidione, cycloheximide, naramycin a, kaken, actidion, actidone, hizarocin, naramycin, neocycloheximide
PubChem CID 6197
ChEBI CHEBI:27641
IUPAC Name 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
SMILES [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1

Specifications

Quantity 100 mg
Formula Weight 281.35
Percent Purity >97%
Chemical Name or Material Cycloheximide

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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