Cimetidine, 98+%, Thermo Scientific Chemicals

Description

H2 histamine receptor antagonist

Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand. It displays antitumor and immunomodulatory activity. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent and is an activator of Nischarin. Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand. It displays antitumor and immunomodulatory activity. Cimetidine competitively inhibits histamine binding to histamine H2 receptors, and suppresses the growth of several tumors, including gastrointestinal cancer. This compound is an anti-angiogenic agent and is an activator of Nischarin. Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output

Solubility
Soluble to 50 mM in water and to 100 mM in DMSO, solubility in HCl (almost transparency).

Notes
Store away from heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Specifications

Chemical Identifiers

• CAS: 51481-61-9
• Molecular Formula: C10H16N6S
• Molecular Weight (g/mol): 252.34
• MDL Number: MFCD00133296
• InChI Key: AQIXAKUUQRKLND-UHFFFAOYSA-N
• Synonym: cimetidine, tagamet, tametin, eureceptor, cimetag, acinil, tratul, cimetidina, dyspamet, ulcedine
• PubChem CID: 2756
• ChEBI: CHEBI:3699
• IUPAC Name: 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
• SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N

• Melting Point: 139°C to 144°C
• Color: White
• Quantity: 25 g
• Merck Index: 14,2279
• Solubility Information: Soluble to 50 mM in water and to 100 mM in DMSO,solubility in HCl (almost transparency).
• Formula Weight: 252.34
• Percent Purity: ≥98%
• Physical Form: Powder
• Chemical Name or Material: Cimetidine

Safety and Handling

Hazard Category	H360
Hazard Statement	GHS H Statement H360 May damage fertility or the unborn child.
Precautionary Statement	P201-P202-P281-P308+P313-P501c
EINECSNumber	257-232-2
RTECSNumber	MF0035500
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only