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  7. Ch 55, Tocris Bioscience™

Ch 55, Tocris Bioscience™

Catalog No. 202050
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent RAR agonist

Highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM).

Chemical Identifiers

CAS 110368-33-7
Molecular Formula C24H28O3
Molecular Weight (g/mol) 364.485
InChI Key FOUVTBKPJRMLPE-FMIVXFBMSA-N
Synonym 3,5-di-tert-butylchalcone, 4-1e-3-3,5-di-tert-butylphenyl-3-oxoprop-1-en-1-yl benzoic acid, 4-3-3,5-di-t-butylphenyl-3-oxo-1-propenyl benzoic acid, e-4-3-3,5-bis 1,1-dimethylethyl phenyl-3-oxo-1-propenyl benzoic acid, benzoic acid, 4-3-3,5-bis 1,1-dimethylethyl phenyl-3-oxo-1-propenyl-, e, 3,5-di-tert-butylchalcone-4'-carboxylic acid, e-4-3,5-di-t-butylphenyl-3-oxopropenyl benzoic acid, 4-3-3,5-di-tert-butylphenyl-3-oxo-1-propenyl benzoic acid, 4-e-3-3,5-ditert-butylphenyl-3-oxo-prop-1-enyl benzoic acid, 4-e-3-3,5-ditert-butylphenyl-3-oxoprop-1-enyl benzoic acid
PubChem CID 6184667
IUPAC Name 4-[(E)-3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid
SMILES CC(C)(C)C1=CC(=CC(=C1)C(=O)C=CC2=CC=C(C=C2)C(=O)O)C(C)(C)C

Specifications

Quantity 50 mg
Formula Weight 364.47
Percent Purity >98%
Chemical Name or Material Ch 55

Safety and Handling

Recommended Storage Store at Room Temperature
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