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STEMCELL Technologies Anti-Human CD45RA, Clone HI100, PE, Size: 100 Tests
Supplier: STEMCELL Technologies 1000320
The HI100 antibody reacts with an extracellular epitope on the CD45RA isoform of CD45 a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily). Alternative splicing of exons 4 5 and 6 that encode the extracellular RA RB and RC polypeptides of CD45 gives rise to several isoforms with molecular masses of 180 - 240 kDa. Excision of exon 4 generates the ~220-kDa CD45RA isoform which is expressed on naïve T cells subsets of B cells and monocytes and medullary thymocytes. CD45RA functions to enhance signaling through both the T cell receptor and B cell receptor. The HI100 antibody is commonly used in combination with antibodies against the CD45RO isoform to discern naïve and memory T cells and is useful for identifying the suppressor/inducer subset of CD4 lymphocytes. The proportion of CD45RA T cells typically decreases with age.
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