CD123 (IL-3 Receptor α) Mouse, anti-Human, RB780, Clone: 7G3, BD Horizon™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB568691	BD Biosciences 568691	25 Tests
BDB568690	BD Biosciences 568690	100 Tests

Description

The 7G3 monoclonal antibody specifically recognizes human CD123, the 70 kDa IL-3 Receptor α (IL-3Rα) chain. CD123 associates with CD131, the 120-140 kDa Common β chain to form the IL-3 Receptor Complex. CD131 is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic progenitors and plays an important role in hematopoietic progenitor cell growth and differentiation. It is also expressed by mast cells, macrophages and a CD5+ B cell subset. This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated IL-8 secretion, and neutrophil transmigration. This antibody has been reported to be useful for immunoprecipitation, Western blot and immunofluorescent staining for flow cytometry. At the Fifth HLDA Workshop, the human IL-3 receptor was designated CD123.

Specifications

• Antigen: CD123 (IL-3 Receptor α)
• Applications: Flow Cytometry
• Host Species: Mouse
• Target Species: Human
• Gene ID (Entrez): 3563
• Isotype: IgG2a κ
• Content And Storage: Refrigerate (2°C to 8°C)

• Clone: 7G3
• Conjugate: RB780
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide
• Immunogen: Human IL-3Ra-transfected cells
• Primary or Secondary: Secondary