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CCMI, Tocris Bioscience™

Catalog No. 383750
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Positive allosteric modulator of α7 nAChR

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Chemical Identifiers

CAS 917837-54-8
Molecular Formula C19H15Cl2N3O2
Molecular Weight (g/mol) 388.248
InChI Key VMAKIACTLSBBIY-UHFFFAOYSA-N
Synonym ccmi, n-4-chlorophenyl-alpha-4-chloro-phenyl amino methylene-3-methyl-5-isoxazoleacet-amide
PubChem CID 67042344
IUPAC Name 3-(4-chloroanilino)-N-(4-chlorophenyl)-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide
SMILES CC1=NOC(=C1)C(=CNC2=CC=C(C=C2)Cl)C(=O)NC3=CC=C(C=C3)Cl

Specifications

Quantity 50 mg
Formula Weight 388.25
Percent Purity >98%
Chemical Name or Material CCMI

Safety and Handling

Recommended Storage Store at -20°C
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