Brucine, Thermo Scientific Chemicals

Description

Brucine is used as a denaturing alcohol, lubricant additive, separation of racemic mixtures. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Brucine is used as a denaturing alcohol, lubricant additive, separation of racemic mixtures. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects.

Solubility
Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 357-57-3
• Molecular Formula: C23H26N2O4
• Molecular Weight (g/mol): 394.471
• MDL Number: MFCD00005942
• InChI Key: RRKTZKIUPZVBMF-VLTSECPOSA-N
• Synonym: brucine, anhydrous, brucine:strychnidin-10-one,2,3-dimethoxy
• PubChem CID: 51413923
• IUPAC Name: (4aR,5aS,8aR,13aS,15aR,15bS)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one
• SMILES: COC1=C(C=C2C(=C1)C34CCN5C3CC6C7C4N2C(=O)CC7OCC=C6C5)OC

• Melting Point: 175°C to 178°C (decomposition)
• Color: White
• Quantity: 100 g
• UN Number: UN1570
• Beilstein: 63046
• Merck Index: 14,1455
• Solubility Information: Soluble in alcohol,chloroform,and benzene,slightly soluble in water,ether,and glycerol
• Optical Rotation: −118° (c=2.5 in Chloroform)
• Formula Weight: 394.47
• Physical Form: Powder
• Chemical Name or Material: Brucine

Safety and Handling

Hazard Category	H300+H330
Hazard Statement	GHS H Statement H300-H330 Fatal if swallowed. Fatal if inhaled.
Precautionary Statement	P260-P264b-P270-P271-P284-P301+P310-P304+P340-P310-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: BRUCINE
EINECSNumber	206-614-7
RTECSNumber	EH8925000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only