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  8. Bosutinib, Tocris Bioscience™

Bosutinib, Tocris Bioscience™

Catalog No. 436150
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Dual Src-Abl inhibitor; antiproliferative

Dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.

Chemical Identifiers

CAS 380843-75-4
Molecular Formula C26H29Cl2N5O3
Molecular Weight (g/mol) 530.45
MDL Number MFCD07367846
InChI Key UBPYILGKFZZVDX-UHFFFAOYSA-N
Synonym bosutinib, bosutinib ski-606, bosulif, 4-2,4-dichloro-5-methoxyphenyl amino-6-methoxy-7-3-4-methyl-1-piperazinyl propoxy-3-quinolinecarbonitrile, bosutinib usan, unii-5018v4aez0, 4-2,4-dichloro-5-methoxyphenyl amino-6-methoxy-7-3-4-methylpiperazin-1-yl propoxy quinoline-3-carbonitrile, 4-2,4-dichloro-5-methoxyanilino-6-methoxy-7-3-4-methylpiperazin-1-yl propoxy quinoline-3-carbonitrile
PubChem CID 5328940
ChEBI CHEBI:39112
IUPAC Name 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
SMILES COC1=CC(NC2=C3C=C(OC)C(OCCCN4CCN(C)CC4)=CC3=NC=C2C#N)=C(Cl)C=C1Cl

Specifications

Quantity 50 mg
Formula Weight 530.45
Percent Purity >99%
Chemical Name or Material Bosutinib

Safety and Handling

Recommended Storage Store at +4°C
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