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BMS 299897, Tocris Bioscience™

Catalog No. 287010
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent γ-secretase inhibitor

Orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

Chemical Identifiers

CAS 290315-45-6
Molecular Formula C24H21ClF3NO4S
Molecular Weight (g/mol) 511.94
InChI Key IZAOBRWCUGOKNH-OAHLLOKOSA-N
Synonym 2-1r-1-4-chlorophenyl sulfonyl 2,5-difluorophenyl amino ethyl-5-fluoro-benzenebutanoic acid, 2-1r-1-4-chlorophenyl sulfonyl 2,5-difluorophenyl amino ethyl-5-fluorobenzenebutanoic acid, 4-2-1r-1-n-2,5-difluorophenyl 4-chlorobenzenesulfonamido ethyl-5-fluorophenyl butanoic acid
PubChem CID 11249248
IUPAC Name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid
SMILES CC(C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

Specifications

Quantity 10 mg
Formula Weight 511.94
Percent Purity >98%
Chemical Name or Material BMS 299897

Safety and Handling

Recommended Storage Store at -20°C
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