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BIO, Tocris Bioscience™

Catalog No. 319450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent GSK-3 inhibitor; also inhibits cdks

Potent ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 = 5 nM). Also inhibits cyclin-dependent kinases (cdks; IC50 values are <100 nM for cdk2 and 5 and sub micromolar for cdk1, cdk4 and cdk9). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro; also promotes proliferation and dedifferentiation in cardiomyocytes.

Negative Control also available.

Chemical Identifiers

CAS 667463-62-9
Molecular Formula C16H10BrN3O2
Molecular Weight (g/mol) 356.179
InChI Key WNWSUJQVZJJGLF-UHFFFAOYSA-N
Synonym bio, 6-bromo-3-3-hydroxyamino indol-2-ylidene-1h-indol-2-one, z,3e-6'-bromo-3-hydroxyimino-1h,1'h-2,3'-biindolyliden-2'-one, 2h-indol-2-one, 6-bromo-3-3e-1,3-dihydro-3-hydroxyimino-2h-indol-2-ylidene-1,3-dihydro-, 3z, 6-bromo-3-3-hydroxyamino indol-2-ylidene indolin-2-one, 2z,3e-6'-bromo-3-hydroxyimino-2,3'-biindolinylidene-2'-one, 6-bromo-3-3-hydroxyamino-2h-indol-2-ylidene-1,3-dihydro-2h-indol-2-one
PubChem CID 24906282
IUPAC Name 6-bromo-3-[3-(hydroxyamino)indol-2-ylidene]-1H-indol-2-one
SMILES C1=CC2=C(C(=C3C4=C(C=C(C=C4)Br)NC3=O)N=C2C=C1)NO

Specifications

Quantity 50 mg
Formula Weight 356.17
Percent Purity >98%
Chemical Name or Material BIO

Safety and Handling

Recommended Storage Store at +4°C
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