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Tocris Bioscience™ BIO 5192
Highly potent and selective inhibitor of integrin α4β1
Supplier: Tocris Bioscience™ 5051/10
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Description
BIO 5192 is a highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.Specifications
| >98% | |
| BIO 5192 | |
| BIO 5192 |
| 10 mg | |
| 817.78 |
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