BAY 41-8543, >98%, Tocris Bioscience™

Description

Guanylyl cyclase (sGC) stimulator

Guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

Specifications

Chemical Identifiers

• CAS: 256498-66-5
• Molecular Formula: C21H21FN8O
• Molecular Weight (g/mol): 420.452
• InChI Key: AQYFUZRYBJBAGZ-UHFFFAOYSA-N
• Synonym: unii-323t2c09sg, 2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl-5-4-morpholinyl-4,6-pyrimidinediamine, 4,6-pyrimidinediamine, 2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl-5-4-morpholinyl, 2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl-5-morpholin-4-yl pyrimidine-4,6-diamine, 2-1-2-fluorophenyl methyl pyrazolo 3,4-b pyridin-3-yl-5-morpholin-4-yl pyrimidine-4,6-diamine
• PubChem CID: 9953906
• IUPAC Name: 2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine
• SMILES: C1COCCN1C2=C(N=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F)N

• Linear Formula: C₂₁H₂₁FN₈O
• Quantity: 50 mg
• Solubility Information: Soluble to 10mM in DMSO with gentle warming
• Formula Weight: 420.44
• Percent Purity: >98%
• Chemical Name or Material: 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamin
• Grade: >98%

Safety and Handling

Recommended Storage

Store at −20°C