Astemizole, 99+%, Thermo Scientific Chemicals

Description

 

Astemizole, is used as a potent and selective H1-receptor antagonist that displays antihistamine and antimalarial activity. It is also been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storag

Specifications

Chemical Identifiers

• CAS: 68844-77-9
• Molecular Formula: C28H31FN4O
• Molecular Weight (g/mol): 458.581
• MDL Number: MFCD00153919
• InChI Key: GXDALQBWZGODGZ-UHFFFAOYSA-N
• Synonym: astemizole, hismanal, histaminos, paralergin, laridal, retolen, alermizol, astemison, astemizol, histamen
• PubChem CID: 2247
• ChEBI: CHEBI:2896
• IUPAC Name: 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine
• SMILES: COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F

• Melting Point: 149°C to 150°C
• Color: White
• Quantity: 50 mg
• Merck Index: 14,856
• Solubility Information: It is soluble in DMSO (25mg/ml ),ethanol (25mg/ml),chloroform,methanol,and water (partly miscible).
• Formula Weight: 458.57
• Percent Purity: ≥99%
• Physical Form: Powder
• Chemical Name or Material: Astemizole

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	272-441-9
RTECSNumber	DD8968000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only