Arsenazo III, Thermo Scientific Chemicals

Description

Arsenazo III (3,6-bis((E)-(2-Arsonophenyl)diazenyl)-4,5-dihydroxynaphthalene-2,7-disulfonic acid, CAS # 1668-00-4) is a metallochrome indicator that is used for detecting calcium levels in plasma and serum.

Suitable for determination of micromolar amounts of calcium

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Arsenazo III is highly specific for calcium and produces absorbance peaks in the 600-660 nm range
• It reacts in slightly acidic conditions, and is soluble in alcohol and semi-soluble in water

Application

• Arsenazo III can detect calcium in permeabilized cells; it is also capable of detecting uranium and thorium
• Arsenazo III has been used in vitro to measure intracellular Ca2+ levels in live neurons alongside patch clamp methods

Specifications

Chemical Identifiers

• CAS: 1668-00-4
• Molecular Formula: C22H18As2N4O14S2
• Molecular Weight (g/mol): 776.363
• MDL Number: MFCD00036695
• InChI Key: TVMZRHVOFZTNET-RIRMOVKSSA-N
• Synonym: arsenazo iii, arsenazo iii sodium salt, 2,2'-1, 8-dihydroxy-3,6-disulfo-2, 7-naphthalene-bis azo dibenzenearsonic acid, 2,7-bis 2-arsonophenylazo-1, 8-dihydroxy-3, 6-naphthalene disulfonic acid, 2,7-bis 2-arsonophenylazo-1,8-dihydroxynaphthalene-3,6-disulfonic acid, 2,7-bis 2-arsonophenylazo chromotropic acid, 2,2'-1,8-dihydroxy-3,6-disulfonaphthylene-2,7-bisazo bisbenzenearsonic acid, 3,6-bis 2-2-arsonophenyl diazen-1-yl-4,5-dihydroxynaphthalene-2,7-disulfonic acid, 3,6-bis 2-2-arsonophenyl diazenyl-4,5-dihydroxy-2,7-naphthalenedisulfonic acid, 3,6-bis 2-2-arsonophenyl hydrazin-1-ylidene-4,5-dioxonaphthalene-2,7-disulfonic acid
• PubChem CID: 9810878
• IUPAC Name: (3Z,6E)-3,6-bis[(2-arsonophenyl)hydrazinylidene]-4,5-dioxonaphthalene-2,7-disulfonic acid
• SMILES: C1=CC=C(C(=C1)NN=C2C(=CC3=C(C2=O)C(=O)C(=NNC4=CC=CC=C4[As](=O)(O)O)C(=C3)S(=O)(=O)O)S(=O)(=O)O)[As](=O)(O)O

• Color: Brown to Purple
• Quantity: 25 g
• UN Number: UN3465
• Beilstein: 5717957
• Formula Weight: 776.37
• Physical Form: Powder
• Chemical Name or Material: Arsenazo III

Safety and Handling

Hazard Category	H301+H331
Hazard Statement	GHS H Statement H301-H331 Toxic if swallowed. Toxic if inhaled.
Precautionary Statement	P261-P264b-P270-P271-P301+P310-P304+P340-P311-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: ORGANOARSENIC COMPOUND, SOLID, N.O.S.
EINECSNumber	216-788-6
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only