AIP1 Mouse, Unlabeled, Clone: 49, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB611620	BD Biosciences 611620	50 μg
BDB611621	BD Biosciences 611621	150 μg

Description

Apoptosis is a selective process of genetically programmed cell death which occurs during normal cell differentiation and development of multicellular organisms. In vertebrates, T cell and neuronal development are probably the best characterized systems for the study of apoptosis. ALG-2 and ALG-3 (apoptosis-linked genes 2 and 3) were identified as low molecular weight Ca²⁺ -binding proteins essential for apoptosis through the activation of the Fas receptor in T cells. ALG-2 Interacting Protein 1 (AIP1/Alix) is a ubiquitous protein that associates with ALG-2 in the cytosol in a Ca²⁺; dependent manner. AIP1 is homologous to the yeast protein, BRO1, which has been implicated in Pkc1p- AP kinase signaling. A truncated form of AIP1 protects against serum starvation-, etoposide-, and staurosporine-induced cell death. In addition, the C-terminal proline rich region of AIP1 facilitates interaction with SH3 domain-containing protein expressed in tumorigenic astrocytes (SETA) and this interaction may be important for mediating DNA damage-dependent apoptosis in astrocytes. Thus, AIP1 interacts with ALG-2 or SETA, or both, during activation of cell death pathways in a variety of cell types.

Host Species: Mouse
Clone: 49
Isotype: IgG1
Species Reactivity [for Features Main]: Rat
Immunogen: Mouse AIP1 aa. 375-580

Immunofluorescence, Western Blotting

Specifications

• Antigen: AIP1
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified
• Description: ALG-2 Interacting Protein 1; Alix

• Clone: 49
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Mouse, Rat
• Immunogen: Mouse AIP1 aa. 375-580
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.