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  7. AM 80, Tocris Bioscience™

AM 80, Tocris Bioscience™

Catalog No. 350750
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

RARα agonist; anticancer agent

Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo.

Chemical Identifiers

CAS 94497-51-5
Molecular Formula C22H25NO3
Molecular Weight (g/mol) 351.45
MDL Number MFCD00866188
InChI Key MUTNCGKQJGXKEM-UHFFFAOYSA-N
Synonym tamibarotene, retinobenzoic acid, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbamoyl benzoic acid, amnolake, tamibaro, amnoid, unii-08v52gz3h9, 4-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl carbamoyl benzoic acid, chembl25202
PubChem CID 108143
ChEBI CHEBI:32181
IUPAC Name 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid
SMILES CC1(C)CCC(C)(C)C2=CC(NC(=O)C3=CC=C(C=C3)C(O)=O)=CC=C12

Specifications

Quantity 50 mg
Formula Weight 351.44
Percent Purity >99%
Chemical Name or Material AM 80

Safety and Handling

Recommended Storage Store at Room Temperature
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