AM 580, Tocris Bioscience™

Description

Retinoic acid analog; RARα agonist

AM 580 is an analog of retinoic acid that acts as a selective RARα agonist (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFNγ synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro.

AM 580 synthesized to Ancillary Material Grade also available.

Specifications

Chemical Identifiers

• CAS: 102121-60-8
• Molecular Formula: C22H25NO3
• Molecular Weight (g/mol): 351.45
• MDL Number: MFCD00673916
• InChI Key: SZWKGOZKRMMLAJ-UHFFFAOYSA-N
• PubChem CID: 2126
• ChEBI: CHEBI:64210
• IUPAC Name: 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-amido)benzoic acid
• SMILES: CC1(C)CCC(C)(C)C2=CC(=CC=C12)C(=O)NC1=CC=C(C=C1)C(O)=O

• Quantity: 50 mg
• Synonym: unii-vz5s5g9zfz, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl carbonyl amino benzoic acid, vz5s5g9zfz, chembl69367, 4-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido benzoic acid, benzoic acid,4-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl carbonyl amino, 4-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl carbonyl aminobenzoic acid, 4-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl carboxamido benzoic acid, 4-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl carbonyl amino benzoic acid, benzoic acid, 4-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl carbonyl amino
• Formula Weight: 351.44
• Percent Purity: >98%
• Chemical Name or Material: AM 580

Safety and Handling

Recommended Storage

Store at Room Temperature