Aluminon, ACS, Thermo Scientific Chemicals

Description

It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 569-58-4
• Molecular Formula: C22H23N3O9
• Molecular Weight (g/mol): 473.438
• MDL Number: MFCD00040925
• InChI Key: AIPNSHNRCQOTRI-UHFFFAOYSA-N
• Synonym: aluminon, ammonium aurintricarboxylate, aurintricarboxylic acid ammonium salt, aurintricarboxylic acid, acs
• PubChem CID: 54729869
• ChEBI: CHEBI:87398
• IUPAC Name: triazanium;5-[(3-carboxy-4-oxidophenyl)-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-oxidobenzoate
• SMILES: C1=CC(=C(C=C1C(=C2C=CC(=O)C(=C2)C(=O)O)C3=CC(=C(C=C3)[O-])C(=O)[O-])C(=O)O)[O-].[NH4+].[NH4+].[NH4+]

• Melting Point: 220°C to 225°C (decomposition)
• pH: 5.3
• Odor: Odorless
• Quantity: 100 g
• Merck Index: 14,322
• Solubility Information: Soluble in water(800g/L).
• Formula Weight: 473.44
• Grade: ACS
• Physical Form: Powder
• Chemical Name or Material: Aluminon

Safety and Handling

Hazard Category	H315-H319
Hazard Statement	GHS H Statement H315-H319 Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
EINECSNumber	209-319-1
RTECSNumber	GU4800000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only