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  7. AK 7, Tocris Bioscience™

AK 7, Tocris Bioscience™

Catalog No. 475450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective SIRT2 inhibitor; brain penetrant

Selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

Chemical Identifiers

CAS 420831-40-9
Molecular Formula C19H21BrN2O3S
Molecular Weight (g/mol) 437.35
MDL Number MFCD03140195
InChI Key IYAYHZZWYNXHEQ-UHFFFAOYSA-N
Synonym ak-7, 3-azepan-1-ylsulfonyl-n-3-bromophenyl benzamide, ak 7, 3-azepane-1-sulfonyl-n-3-bromophenyl benzamide, 3-1-azepanylsulfonyl-n-3-bromophenyl benzamide, sirt2 inhibitor, ak-7, sirt2 inhibitor ii ak-7, benzamide, n-3-bromophenyl-3-hexahydro-1h-azepin-1-yl sulfonyl, ak hplc, n-3-bromophenyl-3-hexahydro-1h-azepin-1-yl sulfonyl benzamide
PubChem CID 1328033
IUPAC Name 3-(azepane-1-sulfonyl)-N-(3-bromophenyl)benzamide
SMILES BrC1=CC=CC(NC(=O)C2=CC(=CC=C2)S(=O)(=O)N2CCCCCC2)=C1

Specifications

Quantity 50 mg
Formula Weight 437.35
Percent Purity >98%
Chemical Name or Material AK 7

Safety and Handling

Recommended Storage Store at +4°C
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