Acetylcholine chloride, 98+%, Thermo Scientific Chemicals

Description

Acetylcholine chloride acts as an endogenous neurotransmitter at cholinergic synapses. The compound has been shown to have ophthalmological uses and can be broken down quickly by choliesterases. Acetylcholine influences many basic cells functions, such as mitosis, cells differentiation, cytoskeletal organization, and cell to cell contact, among other functions. It reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis.The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Acetylcholine chloride acts as an endogenous neurotransmitter at cholinergic synapses. The compound has been shown to have ophthalmological uses and can be broken down quickly by choliesterases. Acetylcholine influences many basic cells functions, such as mitosis, cells differentiation, cytoskeletal organization, and cell to cell contact, among other functions. It reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis.The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Solubility
Soluble in water (600 g/L at 20°C), alcohol, DMSO (36 mg/ml at 25°C), and ethanol (36 mg/ml at 25°C). Insoluble in ether.

Notes
Store away from moisture. Store under dry inert gas. Incompatible with heat,oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 60-31-1
• Molecular Formula: C7H16ClNO2
• Molecular Weight (g/mol): 181.66
• MDL Number: MFCD00011698
• InChI Key: JUGOREOARAHOCO-UHFFFAOYSA-M
• Synonym: acetylcholine chloride, miochol, acecoline, chloroacetylcholine, arterocoline, acecholin, ovisot, ach chloride, azetylcholinchlorid, 2-acetyloxy-n,n,n-trimethylethanaminium chloride
• PubChem CID: 6060
• ChEBI: CHEBI:2417
• IUPAC Name: 2-acetyloxyethyl(trimethyl)azanium;chloride
• SMILES: CC(=O)OCC[N+](C)(C)C.[Cl-]

• Melting Point: 149°C to 152°C
• Quantity: 100 g
• Beilstein: 3571875
• Sensitivity: Very Hygroscopic
• Merck Index: 14,87
• Solubility Information: Soluble in water (600g/L at 20°C),alcohol,DMSO (36mg/ml at 25°C),and ethanol (36mg/ml at 25°C). Insoluble in ether.
• Formula Weight: 181.66
• Percent Purity: ≥98%
• Chemical Name or Material: Acetylcholine chloride

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	200-468-8
RTECSNumber	FZ9800000
TSCA	Yes
Recommended Storage	Keep cold; Store under Argon

SDS

RUO – Research Use Only