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  6. 17451

5-Iodotubercidin, Tocris Bioscience™

Catalog No. 17451
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Quantity:
1 mg
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This item is not returnable. View return policy

Description

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

Chemical Identifiers

CAS 24386-93-4
Molecular Formula C11H13IN4O4
Molecular Weight (g/mol) 392.15
MDL Number MFCD00055131
InChI Key WHSIXKUPQCKWBY-UHFFFAOYNA-N
Synonym 5-iodotubercidin, 5-iodotubericidin, 7-iodo-7-deazaadenosine, 7-iodotubercidin, 2r,3r,4s,5r-2-4-amino-5-iodo-7h-pyrrolo 2,3-d pyrimidin-7-yl-5-hydroxymethyl tetrahydrofuran-3,4-diol, 7-deaza-7-iodoadenosine, chembl99203, 7h-pyrrolo 2,3-d pyrimidin-4-amine,5-iodo-7-b-d-ribofuranosyl, 5-iodo-7-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine
PubChem CID 97297
ChEBI CHEBI:40167
IUPAC Name 2-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol
SMILES NC1=C2C(I)=CN(C3OC(CO)C(O)C3O)C2=NC=N1

Specifications

Quantity 1 mg
Formula Weight 392.15
Percent Purity 97%
Chemical Name or Material 5-Iodotubercidin

Safety and Handling

Recommended Storage Store at -20°C
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