5-Iodotubercidin, Tocris Bioscience™

Description

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

Specifications

Chemical Identifiers

• CAS: 24386-93-4
• Molecular Formula: C11H13IN4O4
• Molecular Weight (g/mol): 392.15
• MDL Number: MFCD00055131
• InChI Key: WHSIXKUPQCKWBY-UHFFFAOYNA-N
• Synonym: 5-iodotubercidin, 5-iodotubericidin, 7-iodo-7-deazaadenosine, 7-iodotubercidin, 2r,3r,4s,5r-2-4-amino-5-iodo-7h-pyrrolo 2,3-d pyrimidin-7-yl-5-hydroxymethyl tetrahydrofuran-3,4-diol, 7-deaza-7-iodoadenosine, chembl99203, 7h-pyrrolo 2,3-d pyrimidin-4-amine,5-iodo-7-b-d-ribofuranosyl, 5-iodo-7-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine
• PubChem CID: 97297
• ChEBI: CHEBI:40167
• IUPAC Name: 2-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol
• SMILES: NC1=C2C(I)=CN(C3OC(CO)C(O)C3O)C2=NC=N1

• Quantity: 1mg
• Formula Weight: 392.15
• Percent Purity: >90%
• Chemical Name or Material: 5-Iodotubercidin

Safety and Handling

Recommended Storage

Store at -20°C