4',7-Dihydroxyisoflavone, 97%, Thermo Scientific Chemicals

Description

4',7-Dihydroxyisoflavone is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers. It protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4′,7-Dihydroxyisoflavone is a phytoestrogen that is suggested to play a role in preventing hormone-induced cancers. It protects against oxidative damage in liver cells induced by 7,12-dimethylbenz[a]anthracene (DMBA). Catalase and superoxide dismutase activity, down-regulated by DMBA, was restored by daidzein.

Solubility
Insoluble in water. Soluble in DMSO (25 mg/ml), ethanol (2 mg/ml), DMF (10 mg/ml), and 1:10 DMSO:PBS (pH 7.2) (0.15 mg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Specifications

Chemical Identifiers

• CAS: 486-66-8
• Molecular Formula: C15H10O4
• Molecular Weight (g/mol): 254.241
• MDL Number: MFCD00016954
• InChI Key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N
• Synonym: daidzein, 4',7-dihydroxyisoflavone, daidzeol, 7,4'-dihydroxyisoflavone, 7-hydroxy-3-4-hydroxyphenyl-4h-chromen-4-one, diadzein, 7-hydroxy-3-4-hydroxyphenyl-4h-1-benzopyran-4-one, 4h-1-benzopyran-4-one, 7-hydroxy-3-4-hydroxyphenyl, 7-hydroxy-3-4-hydroxyphenyl chromen-4-one, 7-hydroxy-3-4-hydroxyphenyl-4-benzopyrone
• PubChem CID: 5281708
• ChEBI: CHEBI:28197
• IUPAC Name: 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one
• SMILES: C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O

• Melting Point: 328°C to 332°C (decomposition)
• Quantity: 25 g
• Beilstein: 231523
• Merck Index: 14,2801
• Solubility Information: Insoluble in water. Soluble in DMSO (25mg/ml),ethanol (2mg/ml),DMF (10mg/ml),and 1:10 DMSO:PBS (pH 7.2) (0.15mg/ml).
• Formula Weight: 254.24
• Percent Purity: 97%
• Chemical Name or Material: 4',7-Dihydroxyisoflavone

Safety and Handling

Hazard Category	H315-H319
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
EINECSNumber	207-635-4
RTECSNumber	DJ3100040
TSCA	No

SDS

RUO – Research Use Only