2-Cyanoethyl diisopropylchlorophosphoramidite, 95%, Thermo Scientific Chemicals

Description

2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3'-hydroxyl groups in the synthesis of oligodeoxyribonucleotides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3′-hydroxyl groups in the synthesis of oligodeoxyribonucleotides.

Solubility
Miscible with chloroform and dichloromethane.

Notes
Reacts violently with water. Incompatible with alcohols and strong bases.

Specifications

Chemical Identifiers

• CAS: 89992-70-1
• Molecular Formula: C9H18ClN2OP
• Molecular Weight (g/mol): 236.68
• MDL Number: MFCD00011544
• InChI Key: QWTBDIBOOIAZEF-UHFFFAOYSA-N
• Synonym: 2-cyanoethyl n,n-diisopropylchlorophosphoramidite, 2-cyanoethyl-n,n-diisopropylchlorophosphoramidite, phosphoramidochloridous acid, bis 1-methylethyl-, 2-cyanoethyl ester, 2-cyanoethoxy diisopropylamino chlorophosphine, 3-chloro diisopropylamino phosphino oxy propanenitrile, 3-chloro-diisopropylamino phosphanyl oxypropanenitrile, 3-chloro diisopropylamino phosphanyl oxy propanenitrile, acmc-20anxd, 2-cyanoethyl diisopropylchloro-phosphoramidite, 2-cyanoethyl diisopropylphosphoramidochloridite
• PubChem CID: 2734844
• IUPAC Name: 3-[chloro-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
• SMILES: CC(C)N(C(C)C)P(OCCC#N)Cl

• Density: 1.061
• Boiling Point: 103°C to 105°C (0.08 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.478
• Quantity: 5 g
• UN Number: UN2845
• Beilstein: 3588525
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with chloroform and dichloromethane.
• Formula Weight: 236.68
• Percent Purity: 95%
• Chemical Name or Material: 2-Cyanoethyl diisopropylchlorophosphoramidite

Safety and Handling

Hazard Category	H250-H314
Hazard Statement	GHS H Statement H250-H252-H314-H318-H302 Catches fire spontaneously if exposed to air. Self-heating in large quantities; may catch fire. Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed.
Precautionary Statement	P210-P222-P260-P264b-P280-P301+P330+P331-P302+P334-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 4.2; Packing Group: I; Proper Shipping Name: PYROPHORIC LIQUIDS, ORGANIC, N.O.S.
TSCA	No
Recommended Storage	Store at -20°C; Store under Argon

SDS

RUO – Research Use Only