1,1-Dimethylbiguanide hydrochloride, Thermo Scientific Chemicals

Description

1,1-Dimethylbiguanide hydrochloride (metformin hydrochloride, CAS # 115-70-4) is the salt of methylated biguanide, a compound exhibiting anti-hyperglycemic properties.

1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 1,1-Dimethylbiguanide consists of two guanidines with methyl substitutions at position 1

• 1,1-Dimethylbiguanide hydrochloride inhibits complex I of the mitochondrial respiratory chain, increasing AMP and activating target genes

• 1,1-Dimethylbiguanide hydrochloride enhances insulin sensitivity and fatty acid oxidation in cells

• 1,1-Dimethylbiguanide hydrochloride may also have antineoplastic action through the mammalian target of rapamycin pathway

• It is suitable for the laboratory research of diabetes, obesity, and related metabolic disorders

• It is also useful for the laboratory study of mammalian target of rapamycin (mTOR) pathways and AMPK ratios within the cell

Specifications

Chemical Identifiers

• CAS: 1115-70-4
• Molecular Formula: C4H12ClN5
• Molecular Weight (g/mol): 165.63
• MDL Number: MFCD00012582
• InChI Key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• Synonym: metformin hydrochloride, 1,1-dimethylbiguanide hydrochloride, metformin hcl, glucophage, riomet, diabefagos, meguan, metformin monohydrochloride, benofomin, denkaform
• PubChem CID: 14219
• IUPAC Name: hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
• SMILES: [H+].[Cl-].CN(C)C(=N)N=C(N)N

• Melting Point: 218°C to 226°C
• Color: White
• Linear Formula: NH₂C(=NH)NHC(=NH)N(CH₃)₂·HCl
• Quantity: 100 g
• Merck Index: 14,5938
• Solubility Information: Soluble in water (50mg/ml),ethanol,and DMSO (50 mM).
• Formula Weight: 165.62
• Physical Form: Powder
• Chemical Name or Material: 1,1-Dimethylbiguanide hydrochloride

Safety and Handling

Hazard Category	H302-H315-H319-H335
Hazard Statement	GHS H Statement H302-H315-H319 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber	214-230-6
RTECSNumber	DU1800000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only