1,1-Dimethylbiguanide Hydrochloride, MP Biomedicals™

Description

1,1-Dimethylbiguanide Hydrochloride, White Powder

• It has various medical uses such as in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2.
• It may also reduce weight gain in people taking atypical antipsychotics. 1,1-Dimethylbiguanide hydrochloride is suitable biguanide agent used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
• 1,1-Dimethylbiguanide, Hydrochloride (Metformin) is a biguanide antihyperglycemic agent. 1,1-Dimethylbiguanide hydrochloride (metformin) is a strong base.
• It forms well defined salts and possessing excellent coordination capacity with transition metals, forming highly colored bidentate chelate complexes.
• Metformin (MET) exists in various forms: diprotonated (H2MET)2+ in strong acidic solution, monoprotonated (HMET)+ in weak acid, MET in neutral and deprotonated (MET)- in strong alkali solution. It is an oral antidiabetic drug.
• Pharmacokinetics of metformin has been studied. Determination of metformin in human plasma has been described by simple HPLC-UV method.[5] Metformin is reported to increase plasma active glucagon-like peptide-1 (GLP-1) in humans

Specifications

Chemical Identifiers

• CAS: 1115-70-4
• Molecular Formula: C4H12ClN5
• Molecular Weight (g/mol): 165.63
• MDL Number: MFCD00012582
• InChI Key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• Synonym: N,N-Dimethylimidodicarbonimidic diamine, 1,1-Dimethylbiguanide hydrochloride, DMGG, LA-6023
• IUPAC Name: hydrogen 1-[(diaminomethylidene)amino]-N,N-dimethylmethanimidamide chloride
• SMILES: [H+].[Cl-].CN(C)C(=N)N=C(N)N

• Color: White
• Melting Point: 214°C to 224°C
• Quantity: 25g
• Solubility Information: Soluble in water (100mg/mL - clear, colorless solution), 95% ethanol; insoluble in ether, acetone or chloroform.
• Physical Form: Powder

Safety and Handling

RTECSNumber	DU1800000
storageNote1	Store at Room Temperature (15-30°C).